Younger Women With Colon Cancer Outlive Men

December 15th, 2009

A new study suggests that estrogen or other hormones could help younger women with colorectal cancer live longer than men with the disease.

“We’ve known for a while that estrogen prevents colorectal cancer, but this is the first study to suggest it may improve outcomes once you have colorectal cancer,” said study co-author Dr. Heinz-Josef Lenz, co-director of gastrointestinal oncology and colorectal cancer at the University of Southern California/Norris Comprehensive Cancer Center, in a statement.

Lenz and colleagues examined medical records of 52,882 patients who had metastatic colorectal cancer over a 16-year period. Women age 18 to 44 years lived an average of three months longer than men — 17 months versus 14 months.

But the effect wasn’t the same for older women. They survived for an average of seven months, compared to nine months for men.

Lenz thinks estrogen levels could be playing a role. Dr. James Abbruzzese, chair of gastrointestinal medical oncology at the University of Texas M. D. Anderson Cancer Center, said in a statement that improvements in care may also be a factor: Those who were diagnosed after 2000 lived longer.

“In terms of the chemotherapy we have available, since 2000 the regimens employ more agents and have become much more aggressive. Therefore, it may be expected to inhibit normal hormonal cycles leading to lower hormonal levels in these women, so other factors may be playing a role as well. It may not just be hormones,” Abbruzzese said.

More women having a healthy breast removed

December 8th, 2009

A small but growing number of women with breast cancer are choosing to have the unaffected breast removed in an effort to prevent a recurrence, researchers reported Monday.

Using data from New York State hospitals, the researchers found that between 1995 and 2005, the prevalence of preventive mastectomy among women with a history of cancer in one breast more than doubled.

The procedure was performed in about 2 percent of all women diagnosed with breast cancer in 1995 and 1996 — rising to just over 4 percent by 2005.

In contrast, there was only a small increase in preventive mastectomies among women who had no personal history of breast cancer but were considered at risk because of a strong family history of the disease.

The findings suggest that while the number of preventive mastectomies performed each year in New York was small, the procedure is becoming more common, the researchers report in the journal Cancer.

The more marked increase among women with a history of breast cancer raises some concerns, senior researcher Dr. Stephen B. Edge, of the Roswell Park Cancer Institute in Buffalo, told Reuters Health.

The central issue, he explained, is that there is no evidence that removing the unaffected breast improves long-term survival.

While preventive mastectomy likely cuts the chances of cancer developing in the second breast, the ultimate impact on survival is a more complicated matter.

Edge noted that among women who are not at high genetic risk of breast cancer — about 95 percent of all breast cancer patients — the odds of developing cancer in the second breast are between 10 percent and 20 percent over 20 to 30 years.

The large majority of those cancers, he added, are detected early and effectively treated.

So in deciding whether to have a preventive mastectomy, women need to consider the uncertain long-term benefits and the risk of complications — which include bleeding, infection and nerve damage.

“Women need to be carefully counseled on the issues of the risks of developing a second cancer, and the largely minimal or no impact this may have on their survival,” Edge said.

The study findings are based on data from hospital discharge records and the New York State cancer registry. Of the nearly 70,000 women who underwent mastectomies between 1995 and 2005, 9 percent — 6,275 women — had one for preventive reasons.

Of women having a preventive mastectomy, 81 percent had a history of breast cancer. The number of these procedures rose from 295 in 1995 to 683 in 2005.

Meanwhile, the number of preventive procedures performed among women with no personal history of breast cancer showed a much a smaller change — 106 in 1995, versus 128 in 2005.

The data cannot offer any potential reasons for the increases, and Edge said there is “clearly” a need for more research into the factors that are influencing women’s decisions on preventive mastectomy.

Sleep Training Helps Ease Insomnia Tied to Arthritis

November 26th, 2009

Cognitive behavioral therapy for insomnia helps improve pain and sleep in older people with osteoarthritis and insomnia, researchers say.

Their study included 23 patients (mean age 69) who received CBT-I and 28 patients (mean age 66.5) who were assigned to a control group that received information on stress management and wellness. The CBT-I program consisted of eight weekly two-hour classes in which they received sleep-training tips and exercises.

Patients in the CBT-I group reported significantly decreased time to fall asleep (an average decrease of 16.9 minutes at the beginning of the study and 11 minutes at one year after treatment). The cognitive behavioral therapy group also had a decrease in wake after sleep-onset times (an average of 37 minutes initially and 19.9 minutes one year later) and pain (improvement of 9.7 points initially and 4.7 points one year later). Increased sleep efficiency was also noted in the CBT-I group (improvement of 13 percent initially and 8 percent one year after treatment), the researchers found.

No significant improvements in any measure were reported in the control group.

The findings suggest that insomnia is not just a symptom of osteoarthritis but is actually a co-existing illness, lead study author Michael V. Vitiello, a professor at the University of Washington in Seattle, said in a news release. About 60 percent of people with osteoarthritis report pain during the night, and better sleep quality can reduce their suffering, he added.

“The particular strength of CBT-I is that once an individual learns how to improve their sleep, study after study has shown that the improvement persists for a year or more,” Vitiello said in the news release.

The study appears in the Aug. 15 issue of the Journal of Clinical Sleep Medicine.

This and other research shows that “CBT-I can not only improve sleep but that improvement of sleep may lead to improvement in co-existing medical or psychiatric illnesses, such as osteoarthritis or depression, and in the case of our study, that these additional benefits can be seen in the long term,” Vitiello said.

Health Tip: Managing Menstrual Cramps

November 22nd, 2009

Menstrual cramps signal an unwelcome time of the month for many women.

The U.S. National Library of Medicine offers these suggestions to help relieve the pain and discomfort of monthly menstrual cramps:

Use an over-the-counter pain reliever, such as naproxen sodium or ibuprofen.
Apply a hot water bottle or heating pad to the abdominal area.
Perform regular exercises, such as walking or pelvic exercises.
Stick to a healthy diet rich in fruits, vegetables and whole grains. Avoid salt, sugar, caffeine and alcohol.
Perform relaxation techniques, such as meditation or yoga.

Teen Athletes Sleep Better Than Couch Potatoes

November 17th, 2009

Athletic teens sleep better than their couch-potato peers and have fewer problems concentrating at school, a new study finds.

Researchers in Switzerland asked 434 adolescents with an average age of 17 to keep a log of their sleep and daytime habits for one week. The 258 student athletes, part of the “Swiss Olympic Classes,” exercised about 17.5 hours a week. The 176 more sedentary teens exercised for about 4.5 hours a week.

The teen athletes reported waking fewer times during the night, higher energy levels during the day and a greater ability to concentrate than their less-active peers.

The study, by researchers at the Basel Psychiatric Hospital of the University of Basel, Switzerland, appears online in the Journal of Adolescent Health.

“This study shows that, in adolescents, being an athlete is predictive of high sleep quality, low daytime tiredness and high concentration during the day,” said Dr. David Rapoport, director of the sleep medicine program at the New York University School of Medicine. “While it is entirely possible that the good sleep and the favorable daytime profile is caused by exercise, the data do not allow us to conclude this directly.”

Rapoport said that there may be reasons other than the increased exercise helping athletes sleep better than others.

“There are other factors, such as having a favorable psychological profile or predisposition, and there may be something about athletes other than exercise, such as self-discipline, which leads to their ability to sleep well,” he said.

Studies in Animals Suggest 2009 H1N1 Virus May Have Biological Advantage Over Seasonal Influenza Viruses

November 14th, 2009

Preliminary findings in ferrets suggest that the novel 2009 H1N1 influenza virus may outcompete human seasonal influenza viruses, researchers say. Tests in animals showed that levels of the 2009 H1N1 virus rose more quickly than levels of the seasonal virus strains, and the new virus caused more severe disease. In line with previous findings by other research groups, the University of Maryland researchers also observed that the novel H1N1 virus was transmitted more easily from infected to uninfected ferrets than either of the two seasonal influenza viruses.

The researchers found no evidence that the 2009 H1N1 virus combined with either of two seasonal flu viruses to form new, so-called reassortant viruses. These findings suggest that while 2009 H1N1 virus probably will predominate in the coming flu season, there may not be biological pressure for the new virus to re-combine with other circulating viruses, the researchers say.

The work was done by Daniel Perez, Ph.D., and colleagues from the University of Maryland. The researchers were supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

“This elegant study, conducted in a useful animal model of human influenza, provides important information about how the 2009 H1N1 influenza virus interacts with other flu virus strains,” says NIAID Director Anthony S. Fauci, M.D. “The results suggest that 2009 H1N1 influenza may outcompete seasonal flu virus strains and may be more communicable as well. These new data, while preliminary, underscore the need for vaccinating against both seasonal influenza and the 2009 H1N1 influenza this fall and winter.”

When the investigators inoculated ferrets with 2009 H1N1 virus plus either seasonal H1N1 virus or seasonal H3N2 virus, the animals became co-infected with both viruses. However, only the 2009 H1N1 virus was then transmitted from co-infected ferrets to uninfected ferrets; there was no evidence that either of the seasonal flu viruses were transmitted between co-infected and uninfected animals. “The H1N1 pandemic virus has a clear biological advantage over the two main seasonal flu strains and all the makings of a virus fully adapted to humans,” says Dr. Perez.

Next, the team conducted experiments to learn whether 2009 H1N1 virus would combine with seasonal flu viruses in co-infected animals to create new reassortant viruses. Some scientists have speculated that reassortant viruses may be more virulent or transmissible than either 2009 H1N1 or seasonal flu viruses alone. The researchers collected virus-containing material from the ferrets’ nasal cavities, but found no evidence of reassortment between the 2009 H1N1 and seasonal influenza strains, either in ferrets that were directly infected with both viruses or in ferrets that came in contact with the co-infected animals.

The investigators’ findings are posted on PLoS Currents: Influenza, a Web site for rapid communication of new scientific data on influenza. Submissions to PLoS Currents: Influenza are screened by a panel of leading influenza experts prior to posting but do not undergo formal peer review. The new research may be submitted later for peer review and eventual publication in scientific journals.

Antibiotics Being Prescribed Less for Respiratory Infections

November 13th, 2009

Prescribing antibiotics to treat respiratory tract infections has dropped significantly in recent years, a new study has found.

That’s mainly the result of fewer young children being seen for ear infections, according to the researchers. But despite a decline overall, prescriptions for broad-spectrum antibiotics, such as azithromycin (Zithromax), and anti-microbial agents known as quinolones have increased, they reported. Such drugs are used to fight more serious infections, such as MRSA and other resistant bacteria.

“There is good news about declining antibiotic use, since inappropriate use of antibiotics can result in bacteria that are resistant to these antibiotics,” said Dr. Marie R. Griffin, a professor of preventive medicine at Vanderbilt University Medical Center and a co-author of the study. “However, overuse of powerful antibiotics remains a problem.”

“Antibiotics should only be used for bacterial infections, and heavy-duty antibiotics should be saved for serious infections,” Griffin said.

Over the last 12 years, she said, use of antibiotics in children has declined 36 percent. “This is mainly due to educational efforts to reduce inappropriate use of antibiotics for viral infections and to a new vaccine — pneumococcal conjugate vaccine for infants, which has reduced ear infections in children,” she said.

For the study, which is published in the Aug. 19 issue of the Journal of the American Medical Association, the researchers looked at the trends in prescriptions for antibiotics from 1995 to 2006, using data from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey.

They found that medical visits for ear infections among children younger than 5 declined 17 percent in that time, and antibiotic prescription rates dropped 27 percent.

The study attributed the decrease to a 36 percent reduction in antibiotic prescriptions for respiratory tract infections. Rate of doctor visits for ear infections fell 33 percent over the study period, and rates of antibiotic prescriptions specifically for ear infections fell 36 percent, the researchers found.

Among those 5 and older, doctor visits for respiratory tract infections remained about the same, but antibiotic prescription rates for those infections dropped18 percent. Prescription rates for antibiotics for other conditions for which antibiotics are rarely indicated dropped 24 percent in this age group, the study found.

In the past decade, initiatives in the United States have urged the judicious use of antibiotics, particularly for acute respiratory tract infection, which is a common reason for people to see a doctor and a frequent reason for antibiotic prescriptions, especially for young children, the researchers noted.

The use and misuse of antibiotics can increase the likelihood that bacteria will become resistant to antibiotics. Infections caused by antibiotic-resistant microorganisms have been associated with increased illness, death and substantial costs, the researchers said.

Dr. Stuart B. Levy, president of the Alliance for the Prudent Use of Antibiotics and a professor of medicine, molecular biology and microbiology at Tufts University School of Medicine, said he thinks the trend toward less antibiotic use is encouraging.

“It’s a wonderful finding,” Levy said. “The message is getting out there. There is a major thrust in the appropriate use of antibiotics — the realization that if we reduce the use of antibiotics, we will reduce the levels of resistance.”

Levy added that it also has become easier for doctors to tell patients they don’t need antibiotics.

“Now patients are saying: ‘If I don’t need the antibiotic, why should I take it?’ That is a good sign,” he said.

People are getting the message that “antibiotics are not cure-alls, and a consequence of antibiotic usage and misuse is the resistance that emerges,” Levy said.

Valcyte Approved for Cytomegalovirus in Children

November 13th, 2009

The U.S. Food and Drug Administration has approved Valcyte (valganciclovir hydrochloride) to prevent cytomegalovirus (CMV) disease in children 4 months to 16 years who are undergoing kidney or heart transplant, Swiss drug maker Roche said Monday.

CMV disease is a common infection among people who have had an organ transplant. Such patients may be infected with CMV before their surgeries, or be receiving organs that are infected, Roche said in a news release. Children are at increased risk of CMV infection and serious complications when their immune systems are suppressed to prevent rejection of donor organs.

CMV infects about 80 percent of the U.S. population, the company said, and in most cases lies dormant in the body. But when the immune system is weakened, CMV complications could affect the lungs, kidneys, nervous system, liver and gastrointestinal tract — potentially leading to serious illness or death.

As part of the approval, the FDA sanctioned a new oral liquid form of the drug to allow for easier use in children, Roche said.

The drug has not been evaluated in transplant patients under 4 months of age, the company said.

Gold nanotech breath test may show lung cancer early

November 12th, 2009

A sensor made with gold nanoparticles can detect lung cancer in a patient’s breath and may offer a diagnosis before tumors show up on an x-ray, Israeli scientists said on Sunday.

The device, which the developers say would be cheap enough for everyday use by family doctors, detected lung cancer with 86 percent accuracy and may offer a way to screen for a disease not usually diagnosed until it has spread and is no longer curable.

It uses sensors based on gold nanoparticles to detect specific compounds — volatile organic compounds (VOC) — that lung cancer patients have in high levels in exhaled breath.

Breath testing is already recognized as a way of linking specific VOCs in exhaled breath to a certain medical conditions. In 2006, researchers found dogs could be trained to smell cancer on the breath of patients with 99 percent accuracy.

Hossam Haick, one of the scientists working on the sensor, said he hoped it could soon allow doctors to have a simple test at hand to screen people during routine appointments.

“Conventional diagnostic methods for lung cancer are unsuitable for widespread screening because they are expensive and occasionally miss tumors,” Haick and colleagues wrote in Nature Nanotechnology.

“This device is not at all expensive. The whole idea in this development was to devise something very sensitive, and very cheap and very portable,” Haick, of the Technion-Israel Institute of Technology in Haifa, told Reuters.

Lung cancer kills 1.3 million people a year and is the leading cause of cancer death across the world. Only 15 percent of patients live more than 5 years, in part because the disease is usually diagnosed so late.

The device developed by Haick and his colleagues is a nine-sensor array consisting of gold nanoparticles combined with different organic groups that respond to various VOCs released by lung tumors.

They tested 56 healthy people and 40 patients who had been diagnosed with lung cancer using conventional methods.

They found the sensor could distinguish the breath of lung cancer patients from the of the control group with more than 86 percent accuracy.

Haick said the patented device needed to be more rigorously tested and obtain approval from drug licensing authorities before it could go into production.

“I would say that could take three to five years,” he said.

Various other methods exist to measure VOCs, including a breath test using color spots, but existing techniques are often expensive, slow and sometimes require the breath to be concentrated or dehumidified first.

Health Tip: When a Loved One Has Diabetes

November 9th, 2009

When a friend or family member is diagnosed with diabetes, you may be unsure of how you can help.

The American Diabetes Association offers these suggestions:

Learn everything you can about diabetes, including what it is and how it’s treated.
There are different types of diabetes with different treatment requirements, so it helps to learn the specifics about your loved one’s condition.
Talk to your loved one about what he or she needs from you, and what’s needed to cope emotionally.
When your loved one asks for help, follow through.
If your loved on needs professional assistance — with diabetes or a related issue — help the person get it.